Stress Illness (also known as Psychophysiologic Disorder or PPD) is one of the most common causes of Medically Unexplained Symptoms (MUS). These are symptoms for which no link to a diseased organ or structure can be found after diagnostic testing. Javier Escobar, MD and colleagues (1) at the Robert Wood Johnson medical school in New Jersey, USA, decided to try a treatment called Cognitive Behavioral Therapy for these patients.